Antisense Sense in Osteoclasts
نویسندگان
چکیده
منابع مشابه
Antisense Translates into Sense
T he paradigm that DNA is the central bank of genetic information within the cell, and that portions of the DNA are copied via transcription to RNA, which is subsequently decoded to synthesize protein in a cell, is basically true throughout cellular evolution. However, it is also true that although this is a general blueprint for regulating how genes are expressed, evolution, with its varied se...
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The post-human genomic era has led to the development of therapies, which specifically target molecular pathways responsible for diseases. The original concept of antisense therapy was to simply turn off gene's activity by a short synthetic DNA sequence, having sequence complementary to mRNA and thus block the production of undesirable protein. However, during the last two decades this concept ...
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ed in the regulation of vascular tone. Whilst pharmacological antagonism of ‚-adrenoceptors is still part of the mainstay treatment for hypertension, ·adrenoreceptor blockade is rarely used as a front line therapy. In the ALLHAT study peripheral ·-blockade in high risk hypertensive patients led to a 25% increase in cardiovascular events and doubled the likelihood of hospital admissions. Althoug...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2016
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2016.06.004